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Ulcerative Colitis Marker IL-6 Indicates Disease Severity

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Children with severe ulcerative colitis are less likely to respond to treatment with elevated levels of inflammatory cytokine interleukin-6, according to recent results.

Inflammatory marker IL-6 indicates , predicts in .

Children with severe ulcerative colitis are less likely to respond to treatment with elevated levels of inflammatory cytokine interleukin-6, according to recent results.

In an ancillary study to the prospective, multicenter OSCI study, researchers evaluated levels of 12 in serum samples collected from 79 children with (ASC). All patients received intravenous corticosteroids (IVCS), and samples were collected on the third day of treatment.

Second-line therapy was needed for 29% of the cohort who were nonresponsive to IVCS. Patients who responded had lower levels of interleukin-6 (IL-6) than those who did not (P=.003 in univariate analysis). Researchers noted a 40% increase in risk for IVCS failure for every 1 pg/mL of IL-6 increase (OR=1.4; 95% CI, 1.1-2.0). No significant differences were observed between patients who did and did not respond to treatment in the levels of other evaluated cytokines.

Inflammatory marker IL-6 indicates disease severity, predicts treatment
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In an ancillary study to the prospective, multicenter OSCI study, researchers evaluated levels of 12 inflammatory cytokines in serum samples collected from 79 children with acute severe ulcerative colitis (ASC). All patients received intravenous

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