Donate

No Tie Between Acne Drug Accutane and Crohns Colitis

Home»News»No Tie Between Acne Drug Accutane and Crohns Colitis

In a case-control study, researchers evaluated 2,159 women with IBD, along with 43,180 matched controls, aged 18 to 46 years. All participants had received one or more prescriptions for oral contraceptives between May 2001 and December 2009. Use of isotretinoin in both groups was recorded to assess its impact on the risk for IBD. Investigators also performed a meta-analysis of five studies measuring the relationship between isotretinoin and IBD.

No Tie Between Acne Drug Accutane and Crohns Colitis

Women receiving isotretinoin therapy for recalcitrant nodulocystic acne are not at increased risk for developing IBD, according to recent results.

In a case-control study, researchers evaluated 2,159 women with IBD, along with 43,180 matched controls, aged 18 to 46 years. All participants had received one or more prescriptions for oral contraceptives between May 2001 and December 2009. Use of isotretinoin in both groups was recorded to assess its impact on the risk for IBD. Investigators also performed a meta-analysis of five studies measuring the relationship between isotretinoin and IBD.

Isotretinoin exposure was observed in 0.46% of patients with IBD, including five cases each of ulcerative colitis and Crohn’s disease; along with 0.44% of controls. Researchers calculated an adjusted RR of 0.99 (95% CI, 0.52-1.90) for IBD among isotretinoin users, with similar RRs for Crohn’s disease (0.91; 95% CI, 0.37-2.25) and ulcerative colitis (1.10; 95% CI, 0.44-2.70). A longer duration of isotretinoin use was not associated with increased IBD risk, with RRs of 0.96 (95% CI, 0.87-1.05) for an additional 30 days and 0.87 (95% CI, 0.66-1.16) after an extra 90 days.

Intentionally misclassifying a random ulcerative colitis case as Crohn’s disease altered the RRs to 0.87 (95% CI, 0.32-2.36) for ulcerative colitis and 1.11 (95% CI , 0.49-2.54) for Crohn’s disease.

No link between isotretinoin use, risk for IBD
Healio
Isotretinoin exposure was observed in 0.46% of patients with IBD, including five cases each of ulcerative colitis and Crohn’s disease; along with 0.44% of controls. Researchers calculated an adjusted RR of 0.99 (95% CI, 0.52-1.90) for IBD among

You must be logged in to post a comment Login

No Guts Know Glory

IDEAS Kids

IDEAS Kids

IBD Adventures