How does fibrosis occur in Crohn’s disease

How does occur in Crohn’s disease

New research has shown that a protein, known as IL-13, could be the key to the development of fibrosis in Crohn’s disease. This breakthrough could help to advance new medicines to treat people suffering with the disease.

Crohn’s disease is a chronic, debilitating condition characterised by and occurring at any point in the tract. Currently there is no cure. One of the major complications of Crohn’s disease is the development of fibrosis — hardening and thickening — in the . This causes the intestine to lose its mobility and it eventually becomes so narrow that food and faeces are unable to pass.

Fibrosis occurs when there is an of the proteins which are normally involved in the tissue , including collagens.

The research team, led by the School of Veterinary Sciences at the , found an increase in and a lack of control of in fibrotic intestine taken from Crohn’s disease patients when compared to normal intestine. The researchers believe that this is related to an increase in a soluble mediator, interleukin 13 (IL-13), previously identified as promoting fibrosis in the lung, liver and kidney.

Read Full Article

How does fibrosis occur in Crohn’s disease?
University of Bristol
Crohn’s disease is a chronic, debilitating condition characterised by inflammation and ulceration occurring at any point in the . Currently there is no cure. One of the major complications of Crohn’s disease is the development of

Leave a Reply