Ensemble Therapeutics Presents Oral Efficacy of First-in-Class Small Molecule Targeting IL-17 for Inflammation in Preclinical Studies

CAMBRIDGE, Mass., Nov 12, 2012 (BUSINESS WIRE) — –On Track to Select Orally Active IL-17 Drug Candidate in early 2013

Ensemble Therapeutics, a biotechnology company developing Ensemblins(TM), a novel class of small molecule therapeutics with the power of biologics, announced today positive preclinical oral efficacy data with its first-in-class small molecule Interleukin-17 (IL-17) antagonists. A presentation at the American College of Rheumatology (ACR) 2012 Annual Meeting, taking place November 9-14, 2012 in Washington, DC, revealed that the company’s Ensemblins have strong as antagonists of IL-17, a pro-inflammatory implicated in multiple inflammatory and such as , , Crohn’s disease and .

“We have made dramatic progress since the first announcement of our small molecule IL-17 antagonist program earlier this year,” said Dr. Michael D. Taylor, CEO of Ensemble Therapeutics. “This data is compelling in showing excellent oral efficacy in vivo for several lead molecules, which puts us solidly on track to nominate an oral drug candidate for clinical development early in 2013.”

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Ensemble Therapeutics Presents Oral Efficacy of First-in-Class Small Molecule
MarketWatch (press release)
the company’s Ensemblins have strong oral activity as antagonists of IL-17, a pro-inflammatory cytokine implicated in multiple inflammatory and autoimmune diseases such as psoriasis, rheumatoid arthritis, Crohn’s disease and inflammatory bowel disease.and more »

About Rob Hill

In 1994, Rob was a fit, healthy 23-year-old, an amateur runner and athlete. Until that time, he had never really been sick. He didn’t even have a regular doctor. When the illness started, it progressed rapidly. Daily diarrhea. Sustained stomach cramps. The diagnosis was Crohn’s disease, an inflammatory condition of the digestive tract. It got worse, and his weight plummeted from 185 to 105 pounds. After a year and a half, it became clear that his large intestine, his colon, needed to be removed. Rob decided he had to do something about it. The Seven Summits campaign, which we call “No Guts Know Glory” grew from Rob’s love of sport, adventure and the outdoors. By taking it to the extreme, and on a global basis, Rob hopes to show people everywhere that having these diseases or having an ostomy, like Rob does, shouldn’t stop you from leading a full life. You may not be able to climb mountains, but there are so many other things you can do. To further this goal, Rob started the Intestinal Disease Education and Awareness Society (IDEAS), from his home base in Vancouver, British Columbia.

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