Crohn’s Disease Patients Refractory To Tumor Necrosis Factor Inhibitors
The Herald |
Crohn’s disease, SPRING HOUSE, PA., OCT. 17, 2012 — /PRNewswire/ — Findings from a Janssen Research & Development, LLC (Janssen)-sponsored Phase 2b trial evaluating the efficacy and safety of STELARA® (ustekinumab) in the treatment of moderate to severe Crohn’s disease appeared today in The New England Journal of Medicine.The results showed that among patients who had previously failed or were intolerant to at least one (TNF) antagonist, a significantly greater proportion receiving intravenous (I.V.) STELARA 6 mg/kg achieved the primary endpoint of clinical response at week 6, defined as a 100-point reduction in the Crohn’s (CDAI), compared with patients receiving placebo (40 percent vs. 24 percent, respectively).  Subsequent maintenance therapy with every eight-week subcutaneous (SC) STELARA among I.V. STELARA induction responders resulted in significantly higher rates of clinical remission at week 22 compared with placebo.  STELARA targets interleukin (IL)-12 and IL-23, cytokines believed to play a role in immune-mediated including Crohn’s disease.   

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About Rob Hill

In 1994, Rob was a fit, healthy 23-year-old, an amateur runner and athlete. Until that time, he had never really been sick. He didn’t even have a regular doctor. When the illness started, it progressed rapidly. Daily diarrhea. Sustained stomach cramps. The diagnosis was Crohn’s disease, an inflammatory condition of the digestive tract. It got worse, and his weight plummeted from 185 to 105 pounds. After a year and a half, it became clear that his large intestine, his colon, needed to be removed. Rob decided he had to do something about it. The Seven Summits campaign, which we call “No Guts Know Glory” grew from Rob’s love of sport, adventure and the outdoors. By taking it to the extreme, and on a global basis, Rob hopes to show people everywhere that having these diseases or having an ostomy, like Rob does, shouldn’t stop you from leading a full life. You may not be able to climb mountains, but there are so many other things you can do. To further this goal, Rob started the Intestinal Disease Education and Awareness Society (IDEAS), from his home base in Vancouver, British Columbia.

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