Crohn’s Disease Linked To Enterovirus., Researchers have discovered that a cohort of children with Crohn’s disease also have a virus in their intestines, known as enterovirus.
The finding was published in the international journal Clinical and Translational Gastroenterology.
One of the authors of the study, Alkwin Wanders, at Uppsala University and Uppsala University Hospital, believes that the results could help better understand the root causes of Crohn’s disease.
Not much is known about what causes Crohn’s disease; there have been over 140 gene mutations associated with condition. Most of the genes that have been identified play a role in immune defense.
Hence, there have been many theories suggesting that the condition could be caused by a lack of immune defense against various different pathogens, which would mean that Crohn’s disease is a result of both environmental and genetic factors.
Researchers at McGill University and Génome Québec Innovation Centre, along with scientists from other Canadian and Belgian institutions, discovered there are DNA variations in a gene that increase susceptibility to developing Crohn’s disease. Their finding was published in Nature Genetics.
Crohn’s diseases is characterized by inflammation of the digestive tract, affecting different parts of the gut, from the mouth down to the anus. Symptoms include: severe stomach ache, weight loss, strictures in the intestines and diarrhea.
The genes associated with the onset of the condition are vital for the immune defense against a certain type of RNA virus.