Avaxia cleared to start human trials of oral for Crohns disease,

A 7-year-old that’s developed a new way to create and deliver an old kind of drug is making the to the clinical stage as it prepares to take its drug for Crohn’s disease and ulcerative colitis into human trials.

The U.S. Food and Drug Administration has cleared the IND application filed by Avaxia , which develops orally administered antibody drugs that act on located in the . Its lead product, AVX-470, was designed to neutralize the effects of an established target for called (PDF).

Antibodies are proteins, so they’re digestible, which is why antibody drugs like Janssen’s Remicade and ’ Humira are injected, Avaxia vice president of corporate development Mike Rivard explained. Avaxia’s antibodies, he continued, are “engineered by nature to resist digestion.” They’re generated in and isolated from the cows’ early milk.

Read more:

Avaxia cleared to start human trials of oral antibody for Crohn’s disease
MedCity News
A 7-year-old pharmaceutical company that’s developed a new way to create and deliver an old kind of drug is making the critical transition to the clinical stage as it prepares to take its drug for Crohn’s disease and ulcerative colitis into human

About Rob Hill

In 1994, Rob was a fit, healthy 23-year-old, an amateur runner and athlete. Until that time, he had never really been sick. He didn’t even have a regular doctor. When the illness started, it progressed rapidly. Daily diarrhea. Sustained stomach cramps. The diagnosis was Crohn’s disease, an inflammatory condition of the digestive tract. It got worse, and his weight plummeted from 185 to 105 pounds. After a year and a half, it became clear that his large intestine, his colon, needed to be removed. Rob decided he had to do something about it. The Seven Summits campaign, which we call “No Guts Know Glory” grew from Rob’s love of sport, adventure and the outdoors. By taking it to the extreme, and on a global basis, Rob hopes to show people everywhere that having these diseases or having an ostomy, like Rob does, shouldn’t stop you from leading a full life. You may not be able to climb mountains, but there are so many other things you can do. To further this goal, Rob started the Intestinal Disease Education and Awareness Society (IDEAS), from his home base in Vancouver, British Columbia.

Leave a Reply