NSAID, acetaminophen use linked to higher risk for active disease in Crohn’s patients, Crohn’s disease patients who reported using nonsteroidal anti-inflammatory drugs more than once per week demonstrated a significantly higher risk for active disease compared with those who used them less often, a speaker said here.
Acetaminophen use also was associated with greater risk for exacerbated Crohn’s disease (CD), Millie D. Long MD, MPH, assistant professor of medicine, gastroenterology and hepatology division at University of North Carolina, said at the American College of Gastroenterology Annual Scientific Meeting. Ulcerative colitis (UC) patients demonstrated no increased risk for active disease from NSAID or acetaminophen use, she said.
Researchers used bivariate statistics and binomial regression models to determine the independent effects of NSAIDs and acetaminophen use on flare-ups among 711 patients with inflammatory bowel disease. All patients, 519 with CD and 192 with UC, were in disease remission.
Patients’ patterns of NSAID and acetaminophen use were determined at study initiation, and disease activity was assessed 6 months later.