Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug.

Complications of IBD Outside the Intestine

  • Joint Symptoms (pain, stiffness, swelling)
  • Sacroililtis
  • Skin Lesions
  • Liver disease (primary sclerosing cholangitis)

It is marketed in the and Canada under the brand names Medrol and Solu-Medrol. It is also available as a generic drug.


Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolone is prescribed is rather long, and is similar to other corticosteroids such as prednisolone.Methylprednisolone

Common uses include arthritis therapy and short-term treatment of bronchial inflammation or due to various . It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. Also for use as a .

Methylprednisolone is also prescribed for nonpenetrating . It has been shown that a dose of 30 mg/kg IV followed by IV drip at 5.4 mg/kg/hr for 23 hours improves sensory and motor recovery if given within eight hours of the injury.

It is also used for vestibular neuritis.

Side Effects

Methylprednisolone has some serious side effects if taken long-term, including weight loss, , osteoporosis and psychosis, especially when used at high dosage. The most serious side effect occurs after the cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed “dose pack” detailing a specific number of pills to take at designated times over a several-day period. Pharmacists sometimes advise that this drug can cause and down moods.

About Robert Hill

I founded IDEAS Intestinal Disease Education and Awareness Society, from my home base in Vancouver, British Columbia. Intestinal Disease Education and Awareness Society IDEAS is established to raise public awareness of intestinal diseases in order to help remove the stigmas associated with these illnesses. The programs of IDEAS help children, youth and young adults learn to live full lives, find acceptance and gain confidence.

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